RNA Pesticides

All of the recent medical research on COVID-19 vaccines has dramatically reduced the cost of producing RNA, opening up new applications for this versatile molecule. One such application is developing targeted pesticides.

In addition to facilitating the formation of proteins, RNA can be used to inhibit the manufacture of specific proteins through a process known as RNA interference (RNAi). In the case of pesticides, this involves identifying a protein that is uniquely essential to the survival of a specific pest. An RNA molecule designed to inhibit production of that protein is then sprayed where the insect will ingest it. When the required protein is no longer produced, the insect is unable to regulate its internal balance of microorganisms, and it dies.

RNA pesticides effectively target only the specific pests for which they are designed, and do not impact other beneficial insects, animals or humans. Researchers are currently evaluating these pesticides on a virus-spreading mite that could play a role in colony collapse disorder.

Other delivery modes are also being tested, including genetically modifying crops to kill the insects that feed on them. This approach has disadvantages in that it can’t be used on existing plants, and many countries have banned GMOs.