Single Molecule Microscopy

A super-resolution desktop microscope has been developed that can visualize, track and image single molecules within a living cell. The technology will make it possible to develop new drugs and bring diagnostic capabilities to a wider audience than ever before.

Nanoimager combines imaging modalities with advanced software to observe particles at a resolution of 20 nanometers in two dimensions, and with a three-dimensional resolution of 50 nanometers. Using high-powered lasers and imaging techniques, the device is not only capable of localizing individual molecules and their position within complex structures, but also follows their movements for a more accurate picture of particle behavior.

The technology will be helpful for investigating pathogens, their life cycles and how they cause disease. It will also enable a more thorough understanding of neural networks and the basis of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. The ability to study a wide variety of biomolecules could lead to earlier diagnosis and treatment of many debilitating diseases in the future.

For information: ONI; Web site: https://oni.bio/nanoimager/