Blood-Boosting Antibody

Researchers may have discovered a way to “switch on” the body’s natural production of red blood cells with the simple injection of an antibody, a breakthrough that could eliminate the need for blood transfusions and help fight a myriad of diseases.

In a routine laboratory experiment on mice, while examining the role of lung cells in immune function, it was discovered that injecting a particular antibody induced a condition in the mice known as “stress erythropoiesis” – a normal reaction to injury or trauma in which the body is prompted to produce more red blood cells. Although more work is required before the technique can even be tested on humans, the findings could have broad implications for medical practice.

In addition to the obvious benefits for battling anemia, the method could be used to treat individuals who, for religious reasons, cannot accept a transfusion. It would also be useful in combat or emergency situations to stabilize those who are injured until they can be given blood. The scientists also believe that the discovery will ultimately represent a significant step forward in treating other conditions, including diabetes, kidney disease and cancer.

For information: Thomas Braciale, University of Virginia School of Medicine, Biomedical Sciences Graduate Program, P.O. Box 800738, 1102 Jordan Hall, Charlottesville, VA 22908; phone: 434-924-9233; email: tjb2r@virginia.edu; Web site: www.medicine.virginia.edu/